background recent evidences have revealed that in more than 65% of microbial infections, biofilms have critical roles. the ability of yeasts to form biofilms on surface of medical devices such as urine catheters is an important reason of the capability of these microorganisms to cause human disease. objectives the aim of this study was to isolate and identify yeasts on the surfaces of urine cat...

background and purpose: despite the availability of various treatments for fungal diseases, there are some limitations in the management of these conditions due to multiple treatment-related side-effects. the present study was designed to investigate the antifungal properties of different extracts from pistacia atlantica desf. materials and methods: different parts of p. atlantica (i.e., dried ...

Here, we report a method for the transformation of Candida glabrata using a heat shock method. The protocol can be used for transformations in single well or in 96-well scale. It has been employed as an alternative method to the electroporation protocol to construct a genome-scale gene deletion collection in the human fungal pathogen Candida glabrata ATCC2001 and related strains. Furthermore, t...

We report a case of Candida glabrata sepsis associated with chorioamnionitis in an in vitro fertilization-assisted pregnancy. There is a strong association between C. glabrata chorioamnionitis and assisted fertility techniques. Candida glabrata chorioamnionitis presents unique management challenges.

Susceptibilities to amphotericin B and fluconazole of 383 Candida species isolated from blood were determined. Candida albicans was the most common species (55.6%), followed by Candida parapsilosis (17.5%), Candida tropicalis (16.5%), Candida glabrata (5.2%), Candida guilliermondii (2.3%), and others (2.9%). All but three isolates, Candida ciferrii, C. tropicalis, and C. glabrata, one each, wer...

Fungicidal effects of histatin-5 against 26 oral isolates belonging to 5 non-albicans Candida species were examined. Fifty microM of histatin-5 killed more than 95% of Candida tropicalis and Candida guilliermondii isolates and more than 90% of Candida parapsilosis and Candida krusei. However, Candida glabrata was less sensitive to the peptide (mean 62.9%). Our results, taken together, demonstra...

Background: Vulvovaginal candidiasis (VVC) is the most frequent fungal disorder in healthy and normal women. Objectives: The aim of this study was to evaluate vitro antifungal susceptibility clinical isolates Candida albicans glabrata, two common candida species Iranian patients with VVC. Methods: One hundred eight candida, including; C. (n = 77) glabrata: 31) were isolated from 108 activity ca...

background and purpose: micrornas are small non-coding rnas with 1924- nucleotides in length. up- or downregulation of many mirnas has been shown by stimulation of toll-like receptors (tlrs) in the innate immune system. up-regulation of mir-146a has been reported by both tlr and heat-killed candida albicans. in this study, we aimed to evaluate the expression of mir-146a in cultured monocyte-der...